Cytochrome P450 Enzyme Inducers- Easy Mnemonic

Cytochrom P450 enzymes are very essential enzymes required for the metabolism of the various medications and drugs. These enzymes can be induced or inhibited by the various drug and compounds we consume. This induction or inhibition can cause unanticipated therapeutic adverse reactions and therapeutic failures.

 Enzyme inducers are the compounds which induce the cytochrome P450 enzymes. They can be drugs or any other chemicals ( eg. food, herbs). Induction of enzyme by a compound can cause the therapeutic failure.

 The list of enzyme inducers is rigorous. It is impossible to remember all of them. But we can remember high yield enzyme inducers with the help of the following mnemonic.

 The mnemonic is: BullShit CRAP GPS iNduces my rage !
Where,
B = Barbiturates
S = St. John's Wort
C = Carbamazepine
R = Rifampin
A = Alcohol (chronic use)
P = Phenytoin
G = Griseofulvin, Ginseng
P = Phenobarbitol
S = Sulfonylureas
N = Nevirapine

I hope this mnemonic will help you remember high yield enzyme inducers. Also check our YouTube video to learn more about enzyme inducers: